Leaving Geneva, retrace your route along the north shore of Lake Geneva. The way has two choices: either a fast freeway or a much slower country road that traces the lake's shore, meandering through the quaint towns lining the lake. Mountains enclose both sides of the valley and on the lower hills, terraced to the water's edge, stretch the acres and acres of vineyards that make this region so well known-the vineyards and the small villages make a beautiful drive. Allow yourself enough time to follow roads that wind down to the villages on the lake and sample some of the region's wonderful wine.
At the east end of Lake Geneva, take a short detour to visit the Castle of Chillon, dramatically perched on its own little peninsula jutting into the lake. After visiting the castle, return to the freeway and continue following the River Rhône as it winds its way down the flat valley. The section of the Rhône Valley between Lake Geneva and the Zermatt turnoff is pretty, but does not have the pristine beauty found so frequently in other Swiss valleys-the road passes through many industrial areas. However, there are countless side valleys and intriguing passes to explore.
For a detailed description of this suggested car rental driving itinerary Auto Europe highly recommends Karen Brown's Guide to Switzerland, Charming Inns & Itineraries.